Organs-on-a-chip
نویسندگان
چکیده
منابع مشابه
Organs-on-a-chip: a new tool for drug discovery.
INTRODUCTION The development of emerging in vitro tissue culture platforms can be useful for predicting human response to new compounds, which has been traditionally challenging in the field of drug discovery. Recently, several in vitro tissue-like microsystems, also known as 'organs-on-a-chip', have emerged to provide new tools for better evaluating the effects of various chemicals on human ti...
متن کاملLooking to the future of organs-on-chip
The realization that immortalized cell lines cultured in 2D flasks do not fully reflect the in vivo behavior of an organ, is not a new concept; however, the ability to reconstruct organ complexity or maintain organ biopsies has not been available until recently [1]. In the last 20 years, lab-on-a-chip (LOAC) technology has become a reality, where the expertise from computer industry of fabricat...
متن کاملTowards Single-Step Biofabrication of Organs on a Chip via 3D Printing.
Organ-on-a-chip engineering employs microfabrication of living tissues within microscale fluid channels to create constructs that closely mimic human organs. With the advent of 3D printing, we predict that single-step fabrication of these devices will enable rapid design and cost-effective iterations in the development stage, facilitating rapid innovation in this field.
متن کاملScaling and systems biology for integrating multiple organs-on-a-chip.
Coupled systems of in vitro microfabricated organs-on-a-chip containing small populations of human cells are being developed to address the formidable pharmacological and physiological gaps between monolayer cell cultures, animal models, and humans that severely limit the speed and efficiency of drug development. These gaps present challenges not only in tissue and microfluidic engineering, but...
متن کاملState-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology.
Integrated approaches using different in vitro methods in combination with bioinformatics can (i) increase the success rate and speed of drug development; (ii) improve the accuracy of toxicological risk assessment; and (iii) increase our understanding of disease. Three-dimensional (3D) cell culture models are important building blocks of this strategy which has emerged during the last years. Th...
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ژورنال
عنوان ژورنال: Toxicology Research and Application
سال: 2017
ISSN: 2397-8473,2397-8473
DOI: 10.1177/2397847317726351